On June 17, Professor Niu Daowen’s team from the State Key Laboratory of Biotherapy (SKLB), in collaboration with Professor Wu Yundong from Peking University Shenzhen Graduate School, published a research article titled "Catalytic Glycosylation for Minimally Protected Donors and Acceptors" in Nature. The study introduces a glycosylation platform that enables selective coupling between unprotected or minimally protected donor and acceptor sugars, producing 1,2-cis-O-glycosides in a catalyst-controlled, site-selective manner. This breakthrough in the field of glycochemistry offers a new method for designing glycosylation reactions controlled by catalysts rather than protective groups, facilitating a deeper exploration of the functions of carbohydrates.

PhD student Dang QiuDi from the State Key Laboratory of Biotherapy and PhD student Deng Yihui from Peking University Shenzhen Graduate School are the co-first authors, with Professor Niu Daowen and Professor Wu Yundong serving as the co-corresponding authors.

Read more from the article link: https://www.nature.com/articles/s41586-024-07695-4.