In March 2022, Professor Wu Haoxing’s research team from West China MR Research Center and Liu Xiaogang’s team from the Singapore University of Technology and Design cooperated to publish a research paper named "Overcoming the Spectral Dependence: A General Strategy for Developing Far-Red and Near-Infrared Ultra-Fluorogenic Tetrazine Bioorthogonal Probes" in Angewandte Chemie (IF: 15.3). A general tetrazine probe design strategy overcomes the spectral dependence of the energy transfer mechanism, endowing excellent fluorogenicity in the NIR window. The high specificity, signal-to-noise ratio, and photostability of the synthesized probes make them highly suited for live-cell bioimaging and theranostics. The paper was also selected as the 'hot paper' in current issue.